The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies
Identifieur interne : 000D45 ( Main/Exploration ); précédent : 000D44; suivant : 000D46The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies
Auteurs : Wei Hu ; Matthew L. Macdonald [États-Unis] ; Daniel E. Elswick ; Robert A. Sweet [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2014.
Abstract
A number of studies have indicated that antagonists of the
Url:
DOI: 10.1111/nyas.12547
PubMed: 25315318
PubMed Central: 4363164
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">A number of studies have indicated that antagonists of the <italic>N</italic>
-methyl-d-aspartate (NMDA) subtypes of glutamate receptors can cause schizophrenia-like symptoms in healthy individuals and exacerbate symptoms in individuals with schizophrenia. These findings have led to the glutamate hypothesis of schizophrenia. Here we review the evidence for this hypothesis in postmortem studies of brain tissue from individuals affected by schizophrenia, summarizing studies of glutamate neuron morphology, of expression of glutamate receptors and transporters, and of the synthesizing and metabolizing enzymes for glutamate and its co-agonists. We found consistent evidence of morphological alterations of dendrites of glutamatergic neurons in the cerebral cortex of subjects with schizophrenia and of reduced levels of the axon bouton marker synaptophysin. There were no consistent alterations of mRNA expression of glutamate receptors, although there has been limited study of the corresponding proteins. Studies of the glutamate metabolic pathway have been limited, although there is some evidence that excitatory amino acid transporter-2, glutamine synthetase, and glutaminase have altered expression in schizophrenia. Future studies would benefit from additional direct examination of glutamatergic proteins. Further advances, such as selective testing of synaptic microdomains, cortical layers, and neuronal subtypes, may also be required to elucidate the nature of glutamate signaling impairments in schizophrenia.</p>
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